Image Alt


‘c’ the difference!


We all know that Vitamin C is important for our skin. There are 100’s of articles, videos and blog posts online advocating the use of Vitamin C. Vitamin C is a potent antioxidant and it is used in skin care primarily to protect against photo-aging and to promote collagen growth. We’ve all heard the buzzwords like ‘Antioxidant’ or ‘Free Radical’ but what do these things mean & why are they important for your skin?

vitamin c as a skin antioxidant

Oxidization is the process that turns a cut apple brown, or causes steel to rust. We know that by applying an antioxidant (like squeezing lemon juice over the cut apple) the reaction can be stopped. Oxidization is a chain reaction that continues indefinitely unless the process is halted by the introduction of an antioxidant. The oxidative process in your skin begins when a stable bond between two molecules is stressed by an aggressor (like UV radiation) which causes these molecules to split. Each of these newly separated molecules (free radicals) now seek to split apart other healthy bonds, releasing more free radicals thereby causing a chain reaction. An antioxidant ‘scavenges’, or bonds with a free radical and halts the oxidative process. The oxidation process in skin can be triggered by dust, pollution, smoke or most commonly UV rays.

l Ascorbic acid – the king of vitamin c

All Vitamin C’s aren’t created equal. A little known fact is that your skin can only utilize Vitamin C in one form – L Ascorbic Acid. All other forms of Vitamin C must first be converted by your skin into L Ascorbic Acid before any antioxidant value is realized. There are many products claiming to be rich in Vitamin C and with strong antioxidant properties, but if they don’t contain L Ascorbic Acid, the benefits of the Vitamin C will be marginal and your skin will not reap the benefits of L Ascorbic Acid. For the rest of this article, all references to Vitamin C specifically relate to L Ascorbic Acid (LAA)

why is oxidation dangerous?

The largest contributor to the development of photo aging & skin cancer development is UV damage. The direct damage that UV Rays cause include direct oxidation of DNA & the generation of free radicals. Your skins only natural defense against UV damage is melanin. Consequently, it becomes immediately clear why lighter skin types (that don’t have melanin) require additional protection against UV assault. We can and should use SPF daily to protect against UV damage, but here’s some information you probably were unaware of – most broad spectrum SPF’s have UV blockers (physical protection) and UV absorbents (chemical protection). These UV absorbents release free radicals as part of their reactive processes. So the unintentional byproduct of most SPF products is the release of free-radicals. It is essential to protect against oxidative damage and potentially skin cancer by including antioxidants as part of your skin care.

skin benefits of vitamin c

vital in collagen production

Your skin is made up of about 60% collagen and after the age of 25, the collagen content decreases by about 1% per year. Collagen is the protein that gives your skin a firm and healthy structure. Vitamin C (LAA) plays a vital role in the formation of collagen

improved uv protection

When Vitamin C (LAA) is combined with SPF, it improves the skins ability to defend against sun damage & slows down the rate of damage from UV assault. It also absorbs the free radicals caused by the chemical UV absorbents contained in broad spectrum SPF preparations. It’s important to note that the Vitamin C (LAA) must be applied BEFORE sun exposure in order to gain the maximum benefit.

accelerated wound healing

Your skin’s wound healing response is to create scar tissue which is predominantly new collagen. Vitamin C (LAA) is required at every stage of the wound healing process: inflammatory, proliferative and maturative. In the inflammatory phase, Vitamin C (LAA) is required for regulation of the white blood cell life cycle & clearance. During the proliferative phase in which collagen is produced, Vitamin C (LAA) is required for creation & maturation of collagen. During these phases, normal levels of Vitamin C (LAA) in the skin drop and additional supplementation is advantageous as the body seeks to maintain availability of Vitamin C (LAA) for collagen synthesis. During the wound healing process, darker skin types may also be prone to PIH (post inflammatory hyperpigmentation) and Vitamin C (LAA) is essential  for these skin types as it is a melanin inhibitor that helps to prevent the deposition of pigmentation.


The production of melanin (pigmentation) is initiated by an enzyme called tyrosinase. Vitamin C (LAA) is a tyrosinase inhibitor and decreases melanin formation. It also breaks up pigmentation situated around the hair follicle. It has shown great results in reducing the appearance of superficial pigmentation & age spots.



oral supplementation is sufficient

Oral supplementation with Vitamin C does transport Vitamin C to the skin, but in insufficient quantities to combat oxidative stress. The levels of Vitamin C (LAA) in the dermis are much lower than the levels in the epidermis. By applying topical Vitamin C (LAA), the levels in the epidermis and dermis are both increased to effectively combat free radicals. In order to maintain adequate protection from UV rays an unwavering reservoir of Vitamin C (LAA) can be achieved by regular application (8 hourly). Once the Vitamin C (LAA) has reached its peak concentration in the skin, it’s concentration (if not supplemented topically) will halve every 4 days.

Vitamin C & niacinamide (Vit B3) can’t be used together

This argument was propagated because of the apparent danger of Ascorbic acid reacting with Niacinamide to produce Niacin (Nicotinic Acid) in the skin which can cause skin to flush as it dilates the blood vessels. This resulting redness may be itchy or burn slightly. Both ingredients have great benefits to the skin, but what is important to understand is what environment they require in order to be effective. Niacinamide requires a neutral pH (around 5.5), and Vitamin C (LAA) requires an acidic pH of between 2.5 – 3.5 to be effective. The correct way to use them would be to use either product and allow it 15-20 minutes to completely absorb before using the other. In this way the pH of one won’t affect the other

what to look for in a vitamin c skin product

  • L Ascorbic Acid is the undisputed King of Vitamin C and is the most important form to look for in a high performance skin care product if you require effective antioxidant protection. The ideal concentration of Vitamin C (LAA) should be 20% since the effectiveness of it as an antioxidant is proportionate to the concentration, but only up to 20%. At higher concentrations the benefits are similar but the side effects and irritation are more pronounced.
  • L Ascorbic Acid is water soluble so it is best presented in a water based solution like a serum.
  • L Ascorbic Acid is effective and stable in an acidic environment of between pH2.5 – 3.5. The pH also provides the effects of a mild peel at this acidity delivering a smoothing effect to the skin. At this pH, the ionic charge is removed from the L Ascorbic molecule and it is transported efficiently through the stratum corneum. The acidic pH also determines the consistency and delivery of the product (serum vs cream for example) since once lipids and thickeners are added to an aqueous solution to make a cream for example, the pH is usually affected and the L Ascorbic Acid will become ineffective.
  • An L Ascorbic serum with 1% Vitamin E and 0.5% Ferulic Acid increases the effectiveness of the Vitamin C by up to 8 fold.
  • The above combination of Vitamin C, Ferulic Acid and Vitamin E may be used in the future for the prevention of skin cancer.
  • When the L Ascorbic Acid is in a micronized form (nano-particles) it penetrates the skin more efficiently.

IntenCE Antioxidant Plasma


National Centre for Biotechnology Information, US National Library of Medicine; “The Roles of Vitamin C in Skin Health”, Nutrients. 2017 Aug; 9(8): 866.

National Centre for Biotechnology Information, US National Library of Medicine; Indian Dermatology Online Journal. 2013 Apr-Jun; 4(2): 143–146.

National Centre for Biotechnology Information, US National Library of Medicine; “Vitamin C: a Wound Healing Perspective” Br J Community Nurs. 2013 Dec;Suppl:S6, S8-11.









Subscribe to our mailing list

* indicates required


  • November 26, 2020

    Enjoyed reading through this, very good stuff, thanks. Arabel Timofei Afra


Leave a Comment: